Year
2025
Paper
KNRUHS Biochemistry Question Paper 2025
Subject
Biochemistry
Phase
1st Year MBBS
View
University Hub1st YearKNRUHSBiochemistry
KNRUHS Biochemistry Question Papers (2025 to 2021)
KNRUHS Biochemistry is the Phase 1 (1st Year) theory and practical paper covering carbohydrate, lipid, protein, and nucleotide metabolism, vitamins and minerals, enzymes, molecular biology, and clinical biochemistry. GeckoMed provides the complete KNRUHS Biochemistry question paper archive from 2025 to 2021, with topic-wise analysis, exam pattern breakdown, and links to viva preparation, practical guides, and study aid charts.
Sourced from official KNRUHS exam archives.
Open KNRUHS Biochemistry papers in the GeckoMed app for offline access. All KNRUHS Biochemistry Question Papers
2025
| Year | Paper | Subject | Phase | View |
|---|---|---|---|---|
| 2025 | KNRUHS Biochemistry Question Paper 2025 | Biochemistry | 1st Year MBBS | Web View |
2024
| Year | Paper | Subject | Phase | View |
|---|---|---|---|---|
| 2024 | KNRUHS Biochemistry Question Paper 2024 | Biochemistry | 1st Year MBBS | Web View |
Year
2024
Paper
KNRUHS Biochemistry Question Paper 2024
Subject
Biochemistry
Phase
1st Year MBBS
View
2023
| Year | Paper | Subject | Phase | View |
|---|---|---|---|---|
| 2023 | KNRUHS Biochemistry Question Paper 2023 | Biochemistry | 1st Year MBBS | Web View |
Year
2023
Paper
KNRUHS Biochemistry Question Paper 2023
Subject
Biochemistry
Phase
1st Year MBBS
View
2022
| Year | Paper | Subject | Phase | View |
|---|---|---|---|---|
| 2022 | KNRUHS Biochemistry Question Paper 2022 | Biochemistry | 1st Year MBBS | Web View |
Year
2022
Paper
KNRUHS Biochemistry Question Paper 2022
Subject
Biochemistry
Phase
1st Year MBBS
View
2021
| Year | Paper | Subject | Phase | View |
|---|---|---|---|---|
| 2021 | KNRUHS Biochemistry Question Paper 2021 | Biochemistry | 1st Year MBBS | Web View |
Year
2021
Paper
KNRUHS Biochemistry Question Paper 2021
Subject
Biochemistry
Phase
1st Year MBBS
View
KNRUHS Biochemistry Exam Pattern
KNRUHS Biochemistry is a 100-mark theory paper examined in the Phase 1 (1st Year) professional examination under the NMC CBME format. The paper duration is 3 hours. It is written alongside Anatomy and Physiology in the 1st Year professional examination.
The paper follows the NMC CBME structure of long essay questions (LEQ), short essay questions (SEQ), and short answer questions (SAQ). Biochemistry LEQs typically integrate a metabolic pathway with its clinical correlations — a Krebs cycle question may extend to cover energy yield and clinical relevance in sepsis or starvation, or a urea cycle question may ask about the consequences of enzyme deficiencies. SEQs cover discrete topics across metabolism, vitamins, and molecular biology at intermediate depth. SAQs test factual recall — enzyme names, cofactors, specific reactions, and clinical conditions caused by pathway defects. The specific mark allocation and question count are visible in the full papers above.
KNRUHS Biochemistry also has a separate practical examination covering qualitative analysis tests (Benedict, Biuret, Ninhydrin, Fehling, Barfoed), urine analysis, and spot test identification, with a viva component.
Topic-wise Analysis: KNRUHS Biochemistry (2021 to 2025)
The following topic areas recur across KNRUHS Biochemistry papers from 2021 to 2025. Frequency classification is based on review of papers in the GeckoMed archive.
Carbohydrate Metabolism
| Topic Area | Exam Relevance | Study Resource |
|---|---|---|
| Krebs cycle — steps, enzymes, energy yield, regulation, clinical significance | Core | Krebs Cycle Diagram |
| Glycolysis — enzymes, regulatory steps, anaerobic vs aerobic yield | Core | Biochemistry Subject Hub |
| Electron transport chain and oxidative phosphorylation — complexes, ATP synthesis | High-yield | Biochemistry Subject Hub |
| HMP shunt — functions, NADPH production, G6PD deficiency | High-yield | Biochemistry Subject Hub |
| Gluconeogenesis — substrates, key enzymes, physiological significance | Recurring | Biochemistry Subject Hub |
Topic Area
Krebs cycle — steps, enzymes, energy yield, regulation, clinical significance
Exam Relevance
Core
Study Resource
Topic Area
Glycolysis — enzymes, regulatory steps, anaerobic vs aerobic yield
Exam Relevance
Core
Study Resource
Topic Area
Electron transport chain and oxidative phosphorylation — complexes, ATP synthesis
Exam Relevance
High-yield
Study Resource
Topic Area
HMP shunt — functions, NADPH production, G6PD deficiency
Exam Relevance
High-yield
Study Resource
Topic Area
Gluconeogenesis — substrates, key enzymes, physiological significance
Exam Relevance
Recurring
Study Resource
Lipid Metabolism
| Topic Area | Exam Relevance | Study Resource |
|---|---|---|
| Beta-oxidation of fatty acids — steps, energy yield, comparison with synthesis | High-yield | Biochemistry Subject Hub |
| Ketone bodies — synthesis, utilisation, ketoacidosis in diabetes and starvation | High-yield | Biochemistry Viva Questions |
| Lipoproteins — classification (VLDL, LDL, HDL), functions, familial disorders | Recurring | Biochemistry Subject Hub |
Topic Area
Beta-oxidation of fatty acids — steps, energy yield, comparison with synthesis
Exam Relevance
High-yield
Study Resource
Topic Area
Ketone bodies — synthesis, utilisation, ketoacidosis in diabetes and starvation
Exam Relevance
High-yield
Study Resource
Topic Area
Lipoproteins — classification (VLDL, LDL, HDL), functions, familial disorders
Exam Relevance
Recurring
Study Resource
Protein and Amino Acid Metabolism
| Topic Area | Exam Relevance | Study Resource |
|---|---|---|
| Urea cycle — steps, enzymes, hyperammonaemia, clinical correlations | Core | Biochemistry Viva Questions |
| Essential amino acids — classification, metabolic fates, deficiency states | High-yield | Amino Acids Mnemonic |
| Inborn errors — PKU (phenylalanine), alkaptonuria (tyrosine), maple syrup urine disease | High-yield | Biochemistry Subject Hub |
| Transamination and deamination — ALT, AST significance in liver disease | Recurring | Biochemistry Viva Questions |
Topic Area
Urea cycle — steps, enzymes, hyperammonaemia, clinical correlations
Exam Relevance
Core
Study Resource
Topic Area
Essential amino acids — classification, metabolic fates, deficiency states
Exam Relevance
High-yield
Study Resource
Topic Area
Inborn errors — PKU (phenylalanine), alkaptonuria (tyrosine), maple syrup urine disease
Exam Relevance
High-yield
Study Resource
Topic Area
Transamination and deamination — ALT, AST significance in liver disease
Exam Relevance
Recurring
Study Resource
Vitamins and Minerals
| Topic Area | Exam Relevance | Study Resource |
|---|---|---|
| B12 and folate — absorption, coenzyme forms, megaloblastic anaemia | Core | Biochemistry Subject Hub |
| Fat-soluble vitamins (A, D, E, K) — functions, deficiency diseases, toxicity | High-yield | Biochemistry Subject Hub |
| Thiamine (B1), niacin (B3) — coenzyme roles, beriberi, pellagra | Recurring | Biochemistry Subject Hub |
Topic Area
B12 and folate — absorption, coenzyme forms, megaloblastic anaemia
Exam Relevance
Core
Study Resource
Topic Area
Fat-soluble vitamins (A, D, E, K) — functions, deficiency diseases, toxicity
Exam Relevance
High-yield
Study Resource
Topic Area
Thiamine (B1), niacin (B3) — coenzyme roles, beriberi, pellagra
Exam Relevance
Recurring
Study Resource
Molecular Biology and Enzymes
| Topic Area | Exam Relevance | Study Resource |
|---|---|---|
| DNA replication — enzymes (helicase, primase, DNA polymerase, ligase), leading vs lagging strand | High-yield | Biochemistry Subject Hub |
| Enzyme kinetics — Michaelis-Menten, Km, Vmax, competitive vs non-competitive inhibition | High-yield | Biochemistry Viva Questions |
| PCR — principle, steps, applications in diagnosis | Recurring | Biochemistry Subject Hub |
Topic Area
DNA replication — enzymes (helicase, primase, DNA polymerase, ligase), leading vs lagging strand
Exam Relevance
High-yield
Study Resource
Topic Area
Enzyme kinetics — Michaelis-Menten, Km, Vmax, competitive vs non-competitive inhibition
Exam Relevance
High-yield
Study Resource
Topic Area
PCR — principle, steps, applications in diagnosis
Exam Relevance
Recurring
Study Resource
Note: Frequency data is based on GeckoMed's analysis of KNRUHS Biochemistry papers from 2021 to 2025. Full question paper content is available in the papers above.
Study Tips for KNRUHS Biochemistry
Metabolic pathways require step-by-step diagram practice. The Krebs cycle, glycolysis, urea cycle, and beta-oxidation all appear as LEQs in KNRUHS Biochemistry papers and earn full marks only when drawn and labelled correctly — enzymes, substrates, products, cofactors, and energy yields at each step. Practise drawing each pathway from memory at least three times before the exam. The Krebs cycle diagram provides the correct structure to learn from.
Integrate clinical correlations into every metabolic pathway. KNRUHS Biochemistry LEQs increasingly include clinical application components under the NMC CBME framework. The Krebs cycle question may ask about its relevance in starvation. The urea cycle question may ask about the clinical consequences of carbamoyl phosphate synthetase deficiency. Learning the pathway alone — without its disease associations — leaves the applied marks on the table.
Vitamins are predictable short answer territory. The vitamin questions in KNRUHS Biochemistry SAQs follow a highly consistent pattern: coenzyme form, reaction it catalyses, deficiency disease and its clinical features. Revise all 13 vitamins in this three-part format. B12 and folate warrant extra attention because they span Biochemistry, Pathology, and General Medicine.
Essential amino acids first, then specific metabolism. The essential amino acid list is a guaranteed SAQ in most KNRUHS Biochemistry papers. The amino acids mnemonic provides reliable retrieval under exam pressure. Once the list is memorised, layer the specific metabolic pathways for high-yield amino acids — phenylalanine (PKU), tyrosine (melanin, catecholamines, thyroid hormones), and tryptophan (serotonin, niacin).
Practical tests follow a fixed three-part answer format. The Biochemistry practical examination at KNRUHS tests qualitative analysis, and marks are awarded for procedure, observation, and inference separately. The biochemistry practical exam questions guide structures answers in this format for every commonly tested reaction. Revising practical tests in this three-part format from the start prevents the common error of stating only the result without the reaction principle.
Molecular biology can be covered in two sessions. The molecular biology section — DNA replication, transcription, translation, PCR, restriction enzymes — has a finite topic pool compared to metabolism. Two focused sessions, one on the central dogma and one on recombinant DNA techniques, covers the full range of KNRUHS molecular biology questions.
Frequently Asked Questions
Are KNRUHS Biochemistry question papers free to download on GeckoMed?
Yes. All KNRUHS Biochemistry question papers from 2021 to 2025 are free to view on the GeckoMed website. The GeckoMed app provides offline access and PDF download after a 4-day free trial, followed by an annual subscription.
Does the KNRUHS Biochemistry paper follow the NMC CBME format?
Yes. KNRUHS conducts Biochemistry examinations under the NMC Competency Based Medical Education framework. The paper includes long essay questions, short essay questions, and short answer questions covering metabolism, vitamins and minerals, enzymes, molecular biology, and clinical biochemistry as per the Phase 1 CBME syllabus.
Is there a separate practical exam for KNRUHS Biochemistry?
Yes. The KNRUHS Biochemistry assessment includes a 100-mark theory paper and a separate practical examination. The practical covers qualitative analysis tests (Benedict, Biuret, Ninhydrin, Fehling, and others), urine analysis, and spot test identification, with a viva component. The biochemistry practical viva questions page covers the most commonly asked practical viva questions.
What is the most important topic in KNRUHS Biochemistry?
Based on analysis of KNRUHS Biochemistry papers from 2021 to 2025, the Krebs cycle and glycolysis are the most consistently tested and mark-dense topics. The urea cycle, essential amino acids, and the clinical correlations of B12 and folate deficiency are also core topics. Carbohydrate metabolism as a whole — glycolysis, Krebs cycle, ETC, gluconeogenesis, glycogen metabolism — forms the foundation of the theory paper.
Are KNRUHS Biochemistry papers useful for students at other universities?
Yes. The NMC CBME framework sets a common Biochemistry syllabus for all Indian medical universities. Topics recurring in KNRUHS papers — Krebs cycle, urea cycle, lipoproteins, vitamins, DNA replication — appear at RGUHS, TNMGRMU, and other universities. Students at other universities should also review their own university's papers alongside the KNRUHS archive.
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